Theme leader: Steve Tollman
Verbal Autopsy with Participatory Action Research (VAPAR) -Expanding the Knowledge Base through Partnerships for Action on Health Equity Nov 2017
Funders: Health Systems Research Initiative from Department for International Development (DFID)/Medical Research Council (MRC)/Wellcome Trust/Economic and Social Research Council (ESRC)
Collaborating Institutions: University of Aberdeen, Mpumalanga Province Department of Health, University of the Witwatersrand and Queen Margaret University. PI:Dr Lucia D’Ambruoso
Health systems are the products of human relationships: between patients and health workers, managers and policy makers, communities and governments. As a whole, these establish norms of who is eligible for care and what can be expected from the health system. In settings, where services are weak and under-funded, care that is unaffordable and unavailable can become socially normal. Communities have substantial knowledge about these interactions and norms, and health workers have considerable power over how health policy is ‘brought alive’ through them. The inputs of health workers and communities however are often overlooked in policy and planning. The project aims to strengthen systems to record and report deaths, institutionalise processes to develop the voices of communities on health priorities, and act on this information in partnership with health workers, managers, planners and policy makers. The process will collect data, analyse, plan and act, and demonstrate ability to bring about change. Providing practical research that is easily understood and ‘owned’ by end users in a process that encourages action will strengthen relationships between patients, health workers and policy makers to support and sustain positive change. The research builds on development work improving health information for poor and rural groups in South Africa. To date, the work has been done with the MRC/Wits Rural Public Health and Health Transitions Research Unit in South Africa and with the provincial health authority to consider what the data are telling us, and how changes can be implemented to respond to the issues identified.
The development work adapted Verbal Autopsy (VA), a method to determine medical causes of death for people who die without a doctor present. We have introduced a system to record new information in VA on factors such as transport and hospital admissions, which often play critical roles in survival. The development work has also built partnerships with communities to tap
into local knowledge on long standing health problems. We have also developed understandings of social and cultural issues affecting health, risk, and how people interact with care using Participatory Action Research (PAR). PAR provides routes to involve people in service delivery. This can empower people to have more say in what health systems provide, which in turn strengthens people’s abilities to protect and promote health. We have developed the work in partnership with the health authority so that the research is of practical use, developed with and for those who require it for decision-making and resource allocation. The new project extends the pilot work into an ongoing system of collaborative problem solving by taking the data and assessments to those who directly provide services, and working at all levels to understand requirements for change. The work will strengthen and enrich the relationships developed with communities, policy makers and planners, and develop new ones with facility and community-based health workers and clinic managers to do team-based research acting towards shared goals. The process will embed a culture of partnership and participation in health systems, helping to generate and use information on the realities of health workers and patients to improve care. We plan to embed the process in the health system, and explore the potential to use it elsewhere. A team of researchers and policy makers from universities and health authorities in developing and developed countries who have shaped health research and policy in Africa for several decades have come together to lead the 5 year programme.
PHIRST – A Prospective Household observational cohort study of Influenza, Respiratory Syncytial virus and other respiratory pathogens community burden and Transmission dynamics in South Africa Dec, 2016
Cheryl Cohen from the Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, South Africa
The aims of this study are to estimate the community burden of influenza and RSV, and to assess the transmission dynamics of influenza and RSV infections in the community. This is a household-level community cohort study, with the pilot phase currently underway, which will run for 3 consecutive studies in 50 households in each site. We are collect baseline data on household composition and medical histories from all members of household, each member of the household will be followed up twice weekly throughout the RSV and influenza season and annually thereafter. Details on respiratory illness symptoms that occur, hospitalisations and deaths from respiratory illness and monthly TB symptom data will also be collected. The data should assist policy makers to understand how many people get infected with these various pathogens, understand why and how they are passed from person to person, use this data to plan interventions like vaccines to special groups of people who are at risk of becoming very ill and to make changes to programmes, like the TB programme to improve TB control.
Engaging the public in priority setting for health in a rural setting in South Africa
PhD Candidate – Aviva Tugendhaft (PRICELESS) Oct, 2017
In South Africa public participation in decision making processes is entrenched in policy documents and formalised in the national Health Act yet practical examples are lacking. As the country aims to delivery Universal health Coverage through a National Health Insurance (NHI) over the next few years policymakers will face challenges in terms of who and what to cover with their limited budget. Engagement methods that are deliberative could be useful in ensuring the public is included in the priority setting process for NHI in South Africa, and developing the capacity of the public to understand the need for trade offs where demands outweigh the available resources. This study is focused on modifying, implementing and evaluating a specific deliberative engagement tool- the CHAT (Choosing Healthplans All Together) tool to determine if it enables public engagement in priority setting for health in a rural setting in South Africa. The study considers whether the CHAT tool in the Bushbuckridge context facilitates a communal decision-making process where values and opinions are expressed and where capacity of the public to understand the need for trade offs is developed. The study will provide practical lessons on how to involve the public in the priority setting process in the South African context and will identify health service priorities for the Bushbuckridge community, which could inform service delivery decisions. For a presentation of the PhD protocol, click here.
Community-level antibiotic access and use in low- and middle-income countries; finding targets for social interventions to improve rational antimicrobial use (ABACUS) Oct 2017
PhD candidate – Fezile Wagner
The overall aim of ABACUS is to compare community-based antibiotic access and consumption practices across a range of low and middle-income countries (LMICs) in Asia and Africa in order to inform the design of, and identify targets for community-based intervention strategies that may be used to promote rational antibiotic use. This project provides a standardized framework for appraising current antibiotic use patterns, demand and access, which may subsequently be used in other LMICs. ABACUS is currently underway in 7 of the INDEPTH HDSSs namely: Agincourt- South Africa, Metlab- Bangladesh, Manhiça- Mozambique, Filabavi- Vietnam, Kintampo and Dodowa- Ghana and Kanchanaburi.
e/mHealth – Vutivi Project (Knowledge) PhD project Dec 2016
Collaboration with MRC/Wits Health Policy Research Group and Warwick Medical School UK, funded by the ESRC and GE Healthcare ltd. (Principle investigator: Jocelyn Watkins)
Introduction: South Africa presents a relevant case study to examine where and how e/mHealth may play a role within the care cycle and assist rural communities in the barriers faced by accessing healthcare. Semi-structured interviews, focus groups and non-participant observations in clinics and in the community with n=256 people including patients with chronic diseases (aged 18-90), pregnant women (18-36), nurses, doctors, clinical associate students, home-based carers, optometrists, traditional healers, community members, key e/mHealth experts and Government policy makers (district, provincial and national Department of Health).
Results: Findings are presented in four case studies:
Case Study 1: Landscape of e/mHealth in rural South Africa to identify the different players/stakeholders involved.
E.g. Digital providers, Front-end users, Mobile operators, Policy advocates, Designers etc.
Case Study 2: Mobile health communication between Patients and Health Worker
E.g. a) MomConnect (DOH national mHealth programme) to register all pregnant women at their first ANC booking and receive staged-based messaging on educational pregnancy advice to their cell phones.
b) Nkateko Phone call reminders from lay health workers to hypertensive patients to remind them to come to their clinic appointment
Case Study 3: Mobile health communication between Health Worker (at the coal face) and Other (Health Worker/Specialist clinician/Website/App)
E.g. a) Stop Stockouts Campaign – patients or health workers send a SMS or call a number to alert the DOH when there is a drug shortage at the clinic or hospital.
b) Web literacy of nurses using search engines such as Google
c) Patient referrals made by district doctors to tertiary doctors via Whatsapp (image or text)
Cast Study 4: Use of Portable Ultrasound for pregnant women
E.g. a) How pregnant women feel about either having an ultrasound or wanting to have one
Conclusion: e/mHealth is feasible and acceptable and to some degree already in use but usually in a ad-hoc informal way. Enhancing healthcare through the use of digital communication has potential where its implementation is integrated within this normalisation
PEECHi (Programme for the Economic Evaluation for Maternal and Child Health interventions) Dec 2016
Collaboration with PRICELESS, Health Systems Trust and the MRC Burden of Disease Unit
This project used economic evaluation to provide evidence for priority setting to guide investments for better maternal, newborn and child health. The focus was on identifying and assessing the most affordable, effective and scaleable interventions to improve maternal and child health in Ehlanzeni district, Mpumalanga Province. The MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), which includes an established population-based research centre with a longitudinal health and socio-demographic information platform, contributed to this by providing empirical data on rural communities in northeast South Africa. This report “Mortality of Children Under 5” alerted the Department of Health that over 50% of children under 5 die at home.
Integrated Chronic Disease Management model – Vunene (Goodwill) study July 2015
Principal investigator: Dr. Soter Ameh
Co-investigators: Dr. Francesca Xavier Gómez-Olivé, Prof. Kathleen Kahn, Prof. Stephen M. Tollman and Prof. Kerstin Klipstein-Grobusch
South Africa faces a dual burden of chronic communicable (e.g., HIV) and non-communicable (e.g., hypertension) diseases. In a response, the National Department of Health initiated the Integrated Chronic Disease Management (ICDM) model as a pilot (on-going) programme in selected primary health care (PHC) facilities in Mpumalanga, North West and Gauteng Provinces in South Africa. The overall goal of the ICDM model is to leverage the positive lessons learned from the use of the tools and systems in HIV programme to scale up services for NCDs; improve the quality of chronic disease care for better health outcomes; reduce chronic disease mortality and morbidity; and more efficiently meet patients’ health needs. The aim of the Vunene study was to contribute to understanding the effectiveness of the ICDM model in improving the quality of chronic disease care and patients’ health outcomes.
A four-year longitudinal study was conducted from January 2011 to December 2014 [two and half years retrospective records review (January 2011 to June 2013) and one and half years prospective study (July 2013 to December 2014)] in 12 PHC facilities in Bushbuckridge sub-district of Mpumalanga Province, north-east South Africa. To better understand the effectiveness of the ICDM model in improving patients’ health outcomes, seven PHC facilities were categorised into the ICDM model facilities (n=435) where the ICDM model was implemented and five comparison facilities (n=443) where the ICDM model was not implemented.
The preliminary result of the structural equation modelling in the ICDM model facilities showed there was regular supply of critical drugs as well as better coherence in HIV and NCD services. However, services in the priority areas of hospital referral, defaulter tracing, pre-packing of medicines, clinic appointment and patient waiting time were not significantly associated with good quality of care; hence the need to strengthen services in these areas in the study setting. The segmented regression analysis showed that the ICDM model had an effect on the month-to-month increase in the percentage of HIV/AIDS patients on antiretroviral treatment with CD4 counts ≥ 350 cells/μl in the ICDM model facilities, but had no effect on the month-to-month changes in hypertension control (blood pressure<140/90 mmHg) for hypertensive patients on antihypertensive treatment in both study arms. This implies that the purpose for which the ICDM model was initiated – to leverage HIV programmes, tools and systems to scale up services for NCDs – is yet to be achieved in the study setting.
The Vunene study was funded by the MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt) South Africa, through the Wellcome Trust, UK; African Doctoral Dissertation Research Fellowship Programme, Nairobi, Kenya; and Fogarty International Center of the National Institutes of Health
Please download this award winning poster….Facility Feedback 2015… to find results from this study.
Engaging Traditional Healers in Agincourt, South Africa Nov 2017
Collaboration with Carolyn Audet, Vanderbilt University
In both rural and urban sub-Saharan Africa, traditional healers typically hold positions of authority within their communities. Unlike physicians, traditional healers are thought to be able to diagnose and treat physical and emotional ailments resulting from such sources as social transgressions, spirits, curses, and sorcery. People seek care from traditional healers due to social acceptability, perceived source of illness, personal relationships between healers and their patients, as well as the perceived fit of a healer’s explanation of illness with patient expectations. Healers often outnumber clinicians, especially in rural or peri-urban areas. In sub- Saharan Africa, it is estimated that 80% of the population have visited a traditional healer. When experiencing illness, it is common for patients to ping-pong back and forth between the allopathic health system and the traditional health system, potentially leading to delays in care, interruptions or abandonment of treatment, and herb-drug interactions.
Initial work sought to understand the relationship between allopathic and traditional conditions by mapping symptoms, with the goal of identifying disease-specific traditional treatments (frequency and duration), expected prognoses and direct treatment costs. With a particular focus on schizophrenia, epilepsy, HIV, and TB we are learning about traditional illnesses associated with these allopathic diagnoses, modes of transmission and acquisition, traditional treatment offered in the Bushbuckridge area, and the costs associated with traditional healer services
Ongoing work seeks to understand whether traditional healers have greater levels of blood-borne infectious pathogens due to occupational procedures, such as traditional vaccinations. Both studies contribute to our long-term aim of establishing a sustainable and acceptable system for traditional healer integration into the health system, thereby improving chronic and acute health outcomes amongst people living in rural South Africa.
Epidemiology and treatment of epilepsy in sub-Saharan Africa (SEEDS) Nov 2017 Collaboration with Professor Charles Newton, KEMRI/Wellcome Trust, Kilifi & Department of Psychiatry, Oxford University
Epilepsy is one of the most serious, common neurological disorders globally and disproportionately affects low- and middle- income countries. As part of a network of INDEPTH sites, epilepsy research in Agincourt has contributed to our understanding of the epidemiology of epilepsy on the African continent. In Agincourt, we’ve gone on to determine the incidence and premature mortality resulting from active convulsive epilepsy as well as began to the define the economic cost of the condition.
Dr. Ryan Wagner, who leads the epilepsy portfolio work in Agincourt has recently been appointed to serve as Secretary to the International League Against Epilepsy’s Global Epidemiology Commission (2017-21) and co-Chair of the Global Cost of Epilepsy Task Force. During his tenure Ryan will use the epidemiologic and economic understanding of epilepsy gleaned from rural South Africa to explore the heterogeneity of the burden of epilepsy across the globe.
Continuing work on epilepsy in Agincourt focuses on examining the epilepsy treatment gap and further defining a cost-effective intervention aimed at reducing the epilepsy treatment gap. This research will provide insight into management of a non-infectious chronic illness the spans all age groups. The development of an intervention will be undertaken in close collaboration with health care service providers.
Additional collaborative work (the QuAEDAf study) with the University of Limoges, funded by Sanofi, seeks to understand the quality of anti-epileptic drugs (AEDs) on the African continent testing the pharmacological potency of AEDs from 8 African countries. This work will contribute to understanding the role the AEDs play in the epilepsy treatment gap.
VAPAR (Phase 2) – Verbal Autopsy with Participatory Action Research (VA-PAR): Developing a people-centred health systems research methodology (Phase 2) Dec 2016
Lucia D’Ambruoso, Ryan Wagner, Kerstin Edin funded by MRC, ESRC, Wellcome Trust, DFID
BACKGROUND: The overall purpose of the research was to develop methods to improve the stock of knowledge on health for marginalized population groups. The work brought together researchers, local service providers and planners to develop methods to combine the insights from Verbal Autopsy (VA) with Participatory Action Research (PAR) in an action-oriented process.
AIM AND OBJECTIVES: The research aimed to elicit the perspectives of three village-based groups in the Agincourt Health and Demographic Surveillance Site (HDSS) on two leading causes of death. Community views on the methods by which health information was generated in the locality, via routine health surveillance, were also sought. The objectives were to engage with local service users and providers in a participatory process to review mortality data and extended COD classifications from Agincourt HDSS, to further amplify these data with local knowledge, to set priorities for local services, and explore the potential for benefits related to empowerment and social inclusion.
METHODS: The three village-based groups operated independently in a series of meetings to verify and amplify extended COD classifications developed from VA data gained in three rounds of Agincourt HDSS surveillance (2012-14) and with new indicators on social and health systems circumstances at the time of death. Two conditions were selected on the basis of (1) high incidence and prevalence identified via the census data and (2) local relevance and community preferences. In the meetings, PAR methods were used to systematize local knowledge and life histories through collective analysis to generate valid forms of evidence on the relationships between problems and their causes, and to articulate action agendas for changes to local services that respond to the issue identified. The discussions also considered how communities view health surveillance and participation in health issues. OUTPUTS: The outputs are a set of locally relevant health priorities, a series of recommendations for the method, and an account of the community’s views on knowledge production and participation in health issues in this setting. Policy-report/s and peer-reviewed articles that focus on the organisation and delivery of community health services in the Agincourt HDSS have also been produced and disseminated (see below).
ARTICLES IN THE CONVERSATION (UK and AFRICA EDITIONS)